Publications

Julie J. Miller*, L. Nicolas Gonzalez Castro*, Samuel McBrayer, Michael Weller, Timothy Cloughesy, Jana, Portnow, Ovidiu Andronesi, Jill S Barnholtz-Sloan, Brigitta G. Baumert, Mitchell S. Berger, Wenya Linda Bi, Ranjit Bindra, Daniel Cahill, Susan M. Chang, Joseph F. Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. Mellinghoff, L. Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Yan H., Andreas von Deimling, Martin van den Bent, William G. Kaelin, Patrick Y. Wen. Isocitrate dehydrogenase (IDH) mutant gliomas: a Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions. 2023, Neuro-oncology 25 (1), 4-25

Kathryn Gunn, Matti Myllykoski, John Z Cao, Manna Ahmed, Bofu Huang, Betty Rouaisnel, Bill H Diplas, Michael M Levitt, Ryan Looper, John G Doench, Keith L Ligon, Harley I Kornblum, Samuel K McBrayer, Hai Yan, Cihangir Duy, Lucy A Godley, Peppi Koivunen, Julie-Aurore Losman. (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers. 2023, Cancer Discovery 13 (6), 1478-1497

Pirozzi CJ and Yan H. The implications of IDH mutations for cancer development and therapy. 2021, Nature Reviews Clinical Oncology 18 (10), 645-661

Matthias Gromeier, Michael C Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, Hai Yan, Yiping He, Annick Desjardins, James E Herndon, Frederick S Varn, Roel G Verhaak, Junfei Zhao, Dani P Bolognesi, Allan H Friedman, Henry S Friedman, Frances McSherry, Andrea M Muscat, Eric S Lipp, Smita K Nair, Mustafa Khasraw, Katherine B Peters, Dina Randazzo, John H Sampson, Roger E McLendon, Darell D Bigner, David M Ashley. Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy. 2021, Nature communications 12 (1), 352

Matthew S Waitkus, Hai Yan. Targeting isocitrate dehydrogenase mutations in cancer: emerging evidence and diverging strategies. 2021, Clinical Cancer Research 27 (2), 383-388

Cheng Xu, Heng Liu, Christopher J Pirozzi, Lee H Chen, Paula K Greer, Bill H Diplas, Liwei Zhang, Matthew S Waitkus, Yiping He, Hai Yan. TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist. 2021, Acta Neuropathologica Communications 9, 1-12

Donghyun D Lee, Martin Komosa, Sumedha Sudhaman, Ricardo Leão, Cindy H Zhang, Joana D Apolonio, Thomas Hermanns, Peter J Wild, Helmut Klocker, Farshad Nassiri, Gelareh Zadeh, Bill H Diplas, Hai Yan, Steven Gallinger, Trevor J Pugh, Vijay Ramaswamy, Michael D Taylor, Pedro Castelo-Branco, Nuno Miguel Nunes, Uri Tabori. Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer. 2021, The Journal of Clinical Investigation 131 (21)

Kathryn Gunn, Matti Myllykoski, John Cao, Bill Diplas, Hai Yan, Lucy A Godley, Peppi Karppinen, Julie-Aurore Losman. The KDM5 Family of Histone Lysine Demethylases Are Targets of R-2-Hydroxyglutarate in IDH Mutant Tumors. 2021, Blood 138, 503

Michael Brown, Gao Zhang, Kevin Stevenson, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, Hai Yan, Yiping He, Annick Desjardins, James Herndon, Frederick Varn, Roel Verhaak, Junfei Zhao, Allan Friedman, Henry Friedman, Frances McSherry, Andrea Muscat, Eric Lipp, Mustafa Khasraw, Katherine Peters, Dina Randazzo, John Sampson, Roger McLendon, Darell Bigner, Matthias Gromeier, Smita Nair, David M Ashley. BIOM-20. TUMOR-INTRINSIC AND PERIPHERAL FEATURES ASSOCIATE WITH SURVIVAL AFTER POLIO VIROTHERAPY IN RECURRENT GBM. 2021, Neuro-Oncology 23 (Supplement_6), vi14-vi15

Pirozzi CJ, Yan H. Hitting Gliomas When They Are Down: Exploiting IDH-Mutant Metabolic Vulnerabilities. Cancer Discov. 2020 Nov;10(11):1629-1631. doi: 10.1158/2159-8290.CD-20-1215. PubMed PMID: 33139340.

Chen LH, Pan C, Diplas BH, Xu C, Hansen LJ, Wu Y, Chen X, Geng Y, Sun T, Sun Y, Zhang P, Wu Z, Zhang J, Li D, Zhang Y, Wu W, Wang Y, Li G, Yang J, Wang X, Xu C, Wang S, Waitkus MS, He Y, McLendon RE, Ashley DM, Yan H*, Zhang L*. The integrated genomic and epigenomic landscape of brainstem glioma. Nat Commun. 2020 Jun 17;11(1):3077. doi: 10.1038/s41467-020-16682-y. PubMed PMID: 32555164; PubMed Central PMCID: PMC7299931. *Corresponding authors.

Junbo Liang, Hong Zhao, Bill H Diplas, Song Liu, Jianmei Liu, Dingding Wang, Yan Lu, Qing Zhu, Jiayu Wu, Wenjia Wang, Hai Yan, Yi-Xin Zeng, Xiaoyue Wang, Yuchen Jiao. Genome-Wide CRISPR-Cas9 Screen Reveals Selective Vulnerability of ATRX-Mutant Cancers to WEE1 Inhibition. 2020, Cancer research 80 (3), 510-523

Mattox AK, Yan H, Bettegowda C. The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors. Neuro Oncol. 2019 Dec 17;21(12):1509-1518. doi: 10.1093/neuonc/noz156. Review. PubMed PMID: 31595305; PubMed Central PMCID: PMC6917400.

Moure CJ, Diplas BH, Chen LH, Yang R, Pirozzi CJ, Wang Z, Spasojevic I, Waitkus MS, He Y, Yan H. CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP. Mol Cancer Res. 2019 Oct;17(10):2042-2050. doi: 10.1158/1541-7786.MCR-19-0309. Epub 2019 Jul 10. PubMed PMID: 31292202; PubMed Central PMCID: PMC6774824.

Liu Y, Carpenter AB, Pirozzi CJ, Yuan H, Waitkus MS, Zhou Z, Hansen L, Seywald M, Odion R, Greer PK, Hawk T, Chin BB, Vaidyanathan G, Zalutsky MR, Yan H, Vo-Dinh T. Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe. Nanotechnology. 2019 Jul 5;30(27):275101. doi: 10.1088/1361-6528/ab0e9c. Epub 2019 Mar 11. PubMed PMID: 30856613; PubMed Central PMCID: PMC6948110.

Donghyun D Lee, Ricardo Leao, Martin Komosa, Marco Gallo, Cindy H Zhang, Tatiana Lipman, Marc Remke, Abolfazl Heidari, Nuno Miguel Nunes, Joana D Apolonio, Aryeh J Price, Ramon Andrade De Mello, Joao S Dias, David Huntsman, Thomas Hermanns, Peter J Wild, Robert Vanner, Gelareh Zadeh, Jason Karamchandani, Sunit Das, Michael D Taylor, Cynthia E Hawkins, Jonathan D Wasserman, Arnaldo Figueiredo, Robert J Hamilton, Mark D Minden, Khalida Wani, Bill Diplas, Hai Yan, Kenneth Aldape, Mohammad R Akbari, Arnavaz Danesh, Trevor J Pugh, Peter B Dirks, Pedro Castelo-Branco, Uri Tabori. DNA hypermethylation within TERT promoter upregulates TERT expression in cancer. 2019, The Journal of clinical investigation 129 (1), 223-229

Chunfeng Qu, Yuting Wang, Pei Wang, Kun Chen, Minjie Wang, Hongmei Zeng, Jianquan Lu, Qianqian Song, Bill H Diplas, Da Tan, Chunsun Fan, Qigao Guo, Zheng Zhu, Huihui Yin, Liping Jiang, Xixi Chen, Hui Zhao, Huan He, Yong Wang, Guangyu Li, Xinyu Bi, Xinming Zhao, Taoyang Chen, Hongping Tang, Chuanguo Lv, Dongmei Wang, Wanqing Chen, Jianguo Zhou, Hong Zhao, Jianqiang Cai, Xiaoyue Wang, Sizhen Wang, Hai Yan, Yi-Xin Zeng, Webster K Cavenee, Yuchen Jiao. Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy. 2019, Proceedings of the National Academy of Sciences 116 (13), 6308-6312

Pan C, Diplas BH, Chen X, Wu Y, Xiao X, Jiang L, Geng Y, Xu C, Sun Y, Zhang P, Wu W, Wang Y, Wu Z, Zhang J, Jiao Y, Yan H*, Zhang L*. Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA. Acta Neuropathol. 2018 Nov 20. [Epub ahead of print] PubMed PMID: 30460397. * Corresponding author.

Diplas BH, Liu H, Yang R, Hansen LJ, Zachem AL, Zhao F, Bigner DD, McLendon RE, Jiao Y, He Y, Waitkus MS*, Yan H*. Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas. Neuro Oncol. 2018 Oct 22. doi: 10.1093/neuonc/noy167. [Epub ahead of print] PubMed PMID: 30346624. * Corresponding author.

Chitneni SK, Yan H, Zalutsky MR. Synthesis and Evaluation of a 18F-Labeled Triazinediamine Analogue for Imaging Mutant IDH1 Expression in Gliomas by PET. ACS Med Chem Lett. 2018 May 1;9(7):606-611. PMCID: PMC6047021.

Pirozzi CJ, Yan H. Improved grading of IDH-mutated astrocytic gliomas. Nat Rev Neurol. 2018 May 31;PubMed PMID: 29855600.

Diplas BH, He X, Brosnan-Cashman JA, Liu H, Chen LH, Wang Z, Moure CJ, Killela PJ, Loriaux DB, Lipp ES, Greer PK, Yang R, Rizzo AJ, Rodriguez FJ, Friedman AH, Friedman HS, Wang S, He Y, McLendon RE, Bigner DD, Jiao Y*, Waitkus MS*, Meeker AK*, Yan H*. The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. Nat Commun. 2018 May 25;9(1):2087. PMC5970234. *Corresponding authors.

Waitkus MS, Diplas BH, Yan H. Biological Role and Therapeutic Potential of IDH Mutations in Cancer. Cancer Cell. 2018 May 14;PubMed PMID: 29805076.

Chitneni SK, Reitman ZJ, Spicehandler R, Gooden DM, Yan H, Zalutsky MR. Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors. Bioorg Med Chem Lett. 2018 Feb 15;28(4):694-699. PubMed PMID: 29366652; NIHMSID: NIHMS936533; PubMed Central PMCID: PMC5817038.

Tiburcio PDB, Xiao B, Berg S, Asper S, Lyne S, Zhang Y, Zhu X, Yan H, Huang LE. Functional requirement of a wild-type allele for mutant IDH1 to suppress anchorage-independent growth through redox homeostasis. Acta Neuropathol. 2018 Feb;135(2):285-298. PubMed PMID: 29288440.

Waitkus MS, Pirozzi CJ, Moure CJ, Diplas BH, Hansen LJ, Carpenter AB, Yang R, Wang Z, Ingram BO, Karoly ED, Mohney RP, Spasojeic I, McLendon RE, Friedman HS, He Y, Bigner DD, Yan H. Adaptive evolution of the GDH2 allosteric domain promotes gliomagenesis by resolving IDH1R132H induced metabolic liabilities. Cancer Res. 2017 Nov 2. pii: canres.1352.2017. doi: 10.1158/0008-5472.CAN-17-1352. [Epub ahead of print] PubMed PMID: 29097607.

Yang R, Chen LH, Hansen LJ, Carpenter AB, Moure CJ, Liu H, Pirozzi CJ, Diplas BH, Waitkus MS, Greer PK, Zhu H, McLendon RE, Bigner DD, He Y, Yan H. Cic loss promotes gliomagenesis via aberrant neural stem cell proliferation and differentiation. 2017, Cancer research 77 (22), 6097-6108

Pirozzi CJ, Carpenter AB, Waitkus MS, Wang CY, Zhu H, Hansen LJ, Chen LH, Greer PK, Feng J, Wang Y, Bock CB, Fan P, Spasojevic I, McLendon RE, Bigner DD, He Y, Yan H. Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression. Mol Cancer Res. 2017 May;15(5):507-520. Epub 2017 Feb 1. PubMed PMID: 28148827; PubMed Central PMCID: PMC5415422.

Chitneni SK, Reitman ZJ, Gooden DM, Yan H, Zalutsky MR. Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butylphenyl sulfonamide analogs Eur J Med Chem. 2016 Aug 25;119:218-30. doi: 10.1016/j.ejmech.2016.04.066. Epub 2016 Apr 28. PubMed PMID: 27163884; PubMed Central PMCID: PMC4893934.

Waitkus MS, Diplas BH, Yan H. Isocitrate dehydrogenase mutations in gliomas. Neuro Oncol. 2016 Jan;18(1):16-26. doi: 10.1093/neuonc/nov136. Epub 2015 Jul 16. Review. PubMed PMID: 26188014.

Zhi-Jian Song, Zachary J Reitman, Zeng-Yi Ma, Jian-Hua Chen, Qi-Lin Zhang, Xue-Fei Shou, Chuan-Xin Huang, Yong-Fei Wang, Shi-Qi Li, Ying Mao, Liang-Fu Zhou, Bao-Feng Lian, Hai Yan, Yong-Yong Shi, Yao Zhao. The genome-wide mutational landscape of pituitary adenomas. 2016, Cell research 26 (11), 1255-1259

Matthew S Waitkus, Bill H Diplas, Hai Yan. Isocitrate dehydrogenase mutations in gliomas. 2015, Neuro-oncology 18 (1), 16-26

Dong-Sheng Huang, Zhaohui Wang, Xu-Jun He, Bill H Diplas, Rui Yang, Patrick J Killela, Qun Meng, Zai-Yuan Ye, Wei Wang, Xiao-Ting Jiang, Li Xu, Xiang-Lei He, Zhong-Sheng Zhao, Wen-Juan Xu, Hui-Ju Wang, Ying-Yu Ma, Ying-Jie Xia, Li Li, Ru-Xuan Zhang, Tao Jin, Zhong-Kuo Zhao, Ji Xu, Sheng Yu, Fang Wu, Junbo Liang, Sizhen Wang, Yuchen Jiao, Hai Yan, Hou-Quan Tao. Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation. 2015, European Journal of Cancer 51 (8), 969-976

Zhang ZY, Chan AK, Ding XJ, Qin ZY, Hong CS, Chen LC, Zhang X, Zhao FP, Wang Y, Wang Y, Zhou LF, Zhuang Z, Ng HK*, Yan H*, Yao Y, Mao Y*. TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas. Oncotarget. 2015 Jul 9. [Epub ahead of print] PubMed PMID: 26314843. *Corresponding authors.

Reitman ZJ, Sinenko SA, Spana EP, Yan H. Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila. Blood. 2015 Jan 8;125(2):336-45. Epub 2014 Nov 14. PubMed PMID: 25398939; PubMed Central PMCID: PMC4287640.

Jie Feng, Shuyu Hao, Changcun Pan, Yu Wang, Zhen Wu, Junting Zhang, Hai Yan, Liwei Zhang, Hong Wan. The H3. 3 K27M mutation results in a poorer prognosis in brainstem gliomas than thalamic gliomas in adults. 2015, Human pathology 46 (11), 1626-1632

Reitman ZJ, Duncan CG, Poteet E, Winters A, Yan LJ, Gooden DM, Spasojevic I, Boros LG, Yang SH, Yan H. Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia. J Biol Chem. 2014 Aug 22;289(34):23318-28. Epub 2014 Jul 1. PubMed PMID: 24986863; PubMed Central PMCID: PMC4156049.

Killela PJ^, Pirozzi CJ^, Reitman ZJ, Jones S, Rasheed BA, Lipp E, Friedman H, Friedman AH, He Y, McLendon RE, Bigner DD, Yan H. The genetic landscape of anaplastic astrocytoma. Oncotarget. 2014 Mar 30;5(6):1452-7. PubMed PMID: 24140581; PubMed Central PMCID: PMC4039223. ^Equal contribution.

Killela PJ^, Pirozzi CJ^, Healy P, Reitman ZJ, Lipp E, Rasheed BA, Yang R, Diplas BH, Wang Z, Greer PK, Zhu H, Wang CY, Carpenter AB, Friedman H, Friedman AH, Keir ST, He J, He Y, McLendon RE, Herndon JE 2nd, Yan H*, Bigner DD. Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas. Oncotarget. 2014 Mar 30;5(6):1515-25. PubMed PMID: 24722048; PubMed Central PMCID: PMC4039228. *Corresponding authors. ^Equal contribution.

Liwei Zhang, Lee H Chen, Hong Wan, Rui Yang, Zhaohui Wang, Jie Feng, Shaohua Yang, Siân Jones, Sizhen Wang, Weixin Zhou, Huishan Zhu, Patrick J Killela, Junting Zhang, Zhen Wu, Guilin Li, Shuyu Hao, Yu Wang, Joseph B Webb, Henry S Friedman, Allan H Friedman, Roger E McLendon, Yiping He, Zachary J Reitman, Darell D Bigner, Hai Yan. Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. Nature genetics 46 (7), 726-730

Haizhong Feng, Giselle Y Lopez, Chung Kwon Kim, Angel Alvarez, Christopher G Duncan, Ryo Nishikawa, Motoo Nagane, An-Jey A Su, Philip E Auron, Matthew L Hedberg, Lin Wang, Jeffery J Raizer, John A Kessler, Andrew T Parsa, Wei-Qiang Gao, Sung-Hak Kim, Mutsuko Minata, Ichiro Nakano, Jennifer R Grandis, Roger E McLendon, Darell D Bigner, Hui-Kuan Lin, Frank B Furnari, Webster K Cavenee, Bo Hu, Hai Yan, Shi-Yuan Cheng. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. 2014, The Journal of clinical investigation 124 (9), 3741-3756

Reitman ZJ, Pirozzi CJ, Yan H. Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors. Acta Neuropathol. 2013 Dec;126(6):789-92. PubMed PMID: 24217890; PubMed Central PMCID: PMC3888653.

Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P, Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN, McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Privé GG, Bigner DD, Lasorella A, Rabadan R, Iavarone A. The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet. 2013 Oct;45(10):1141-9. Epub 2013 Aug 5. PubMed PMID: 23917401; PubMed Central PMCID: PMC3799953.

Hodges TR, Choi BD, Bigner DD, Yan H, Sampson JH. Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review. J Neurosurg. 2013 Jun;118(6):1176-80. Epub 2013 Apr 12. Review. PubMed PMID: 23581583; PubMed Central PMCID: PMC3672384.

Pirozzi CJ, Reitman ZJ, Yan H. Releasing the block: setting differentiation free with mutant IDH inhibitors. Cancer Cell. 2013 May 13;23(5):570-2. PubMed PMID: 23680144.

Killela PJ^, Reitman ZJ^, Jiao Y^, Bettegowda C, Agrawal N, Diaz LA Jr, Friedman AH, Friedman H, Gallia GL, Giovanella BC, Grollman AP, He TC, He Y, Hruban RH, Jallo GI, Mandahl N, Meeker AK, Mertens F, Netto GJ, Rasheed BA, Riggins GJ, Rosenquist TA, Schiffman M, Shih IeM, Theodorescu D, Torbenson MS, Velculescu VE, Wang TL, Wentzensen N, Wood LD, Zhang M, McLendon RE, Bigner DD, Kinzler KW, Vogelstein B*, Papadopoulos N, Yan H*. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6021-6. Epub 2013 Mar 25. PubMed PMID: 23530248; PubMed Central PMCID: PMC3625331. *Corresponding authors. ^Equal contribution.

Changcun Guo, Lee H Chen, Yafen Huang, Chun-Chi Chang, Ping Wang, Christopher J Pirozzi, Xiaoxia Qin, Xuhui Bao, Paula K Greer, Roger E McLendon, Hai Yan, Stephen T Keir, Darell D Bigner, Yiping He. KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. 2013, Oncotarget 4 (11), 2144

Jin G^, Reitman ZJ^, Duncan CG, Spasojevic I, Gooden DM, Rasheed BA, Yang R, Lopez GY, He Y, McLendon RE, Bigner DD, Yan H. Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas. Cancer Res. 2013 Jan 15;73(2):496-501. Epub 2012 Nov 30. PubMed PMID: 23204232; PubMed Central PMCID: PMC3548957. ^Equal contribution.

Duncan CG^, Barwick BG^, Jin G, Rago C, Kapoor-Vazirani P, Powell DR, Chi JT, Bigner DD, Vertino PM*, Yan H*. A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. Genome Res. 2012 Dec;22(12):2339-55. Epub 2012 Aug 16. PubMed PMID: 22899282; PubMed Central PMCID: PMC3514664. *Corresponding authors. ^Equal contribution.

Reitman ZJ, Choi BD, Spasojevic I, Bigner DD, Sampson JH, Yan H. Enzyme redesign guided by cancer-derived IDH1 mutations. Nat Chem Biol. 2012 Nov;8(11):887-9. Epub 2012 Sep 23. PubMed PMID: 23001033; PubMed Central PMCID: PMC3487689.

Jin G, Pirozzi CJ, Chen LH, Lopez GY, Duncan CG, Feng J, Spasojevic I, Bigner DD, He Y, Yan H. Mutant IDH1 is required for IDH1 mutated tumor cell growth. Oncotarget. 2012 Aug;3(8):774-82. PubMed PMID: 22885298; PubMed Central PMCID: PMC3478455.

Jiao Y^, Killela PJ^, Reitman ZJ^, Rasheed AB, Heaphy CM, de Wilde RF, Rodriguez FJ, Rosemberg S, Oba-Shinjo SM, Nagahashi Marie SK, Bettegowda C, Agrawal N, Lipp E, Pirozzi C, Lopez G, He Y, Friedman H, Friedman AH, Riggins GJ, Holdhoff M, Burger P, McLendon R, Bigner DD, Vogelstein B, Meeker AK, Kinzler KW, Papadopoulos N, Diaz LA*, Yan H*. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget. 2012 Jul;3(7):709-22. PubMed PMID: 22869205; PubMed Central PMCID: PMC3443254. *Corresponding authors. ^Equal contribution.

Siân Jones, Meng Li, D Williams Parsons, Xiaosong Zhang, Jelle Wesseling, Petra Kristel, Marjanka K Schmidt, Sanford Markowitz, Hai Yan, Darell Bigner, Ralph H Hruban, James R Eshleman, Christine A Iacobuzio‐Donahue, Michael Goggins, Anirban Maitra, Sami N Malek, Steve Powell, Bert Vogelstein, Kenneth W Kinzler, Victor E Velculescu, Nickolas Papadopoulos. Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. 2012, Human mutation 33 (1), 100-103

Wortham M, Yan H. Apples to origins: identifying brain tumor stem cell genes by comparing transcriptomes of normal and cancer stem cells. Cancer Discov. 2012 Jun;2(6):492-4. PubMed PMID: 22684456; PubMed Central PMCID: PMC3375910.

Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG Jr. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature. 2012 Feb 15;483(7390):484-8. doi: 10.1038/nature10898. PubMed PMID: 22343896; PubMed Central PMCID: PMC3656605.

Christopher M Heaphy, Roeland F De Wilde, Yuchen Jiao, Alison P Klein, Barish H Edil, Chanjuan Shi, Chetan Bettegowda, Fausto J Rodriguez, Charles G Eberhart, Sachidanand Hebbar, G Johan Offerhaus, Roger McLendon, B Ahmed Rasheed, Yiping He, Hai Yan, Darell D Bigner, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie, Gregory J Riggins, Kenneth W Kinzler, Bert Vogelstein, Ralph H Hruban, Anirban Maitra, Nickolas Papadopoulos, Alan K Meeker. Altered telomeres in tumors with ATRX and DAXX mutations. 2011, Science 333 (6041), 425-425

D Williams Parsons, Meng Li, Xiaosong Zhang, Siân Jones, Rebecca J Leary, Jimmy Cheng-Ho Lin, Simina M Boca, Hannah Carter, Josue Samayoa, Chetan Bettegowda, Gary L Gallia, George I Jallo, Zev A Binder, Yuri Nikolsky, James Hartigan, Doug R Smith, Daniela S Gerhard, Daniel W Fults, Scott VandenBerg, Mitchel S Berger, Suely Kazue Nagahashi Marie, Sueli Mieko Oba Shinjo, Carlos Clara, Peter C Phillips, Jane E Minturn, Jaclyn A Biegel, Alexander R Judkins, Adam C Resnick, Phillip B Storm, Tom Curran, Yiping He, B Ahmed Rasheed, Henry S Friedman, Stephen T Keir, Roger McLendon, Paul A Northcott, Michael D Taylor, Peter C Burger, Gregory J Riggins, Rachel Karchin, Giovanni Parmigiani, Darell D Bigner, Hai Yan, Nick Papadopoulos, Bert Vogelstein, Kenneth W Kinzler, Victor E Velculescu. The genetic landscape of the childhood cancer medulloblastoma. 2011, science 331 (6016), 435-439

Guo C, Pirozzi CJ, Lopez GY, Yan H. Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target. Curr Opin Neurol. 2011 Dec;24(6):648-52. Review. PubMed PMID: 22002076; PubMed Central PMCID: PMC3640434.

Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH, Rodriguez FJ, Cahill DP, McLendon R, Riggins G, Velculescu VE, Oba-Shinjo SM, Marie SK, Vogelstein B*, Bigner D, Yan H*, Papadopoulos N*, Kinzler KW*. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science. 2011 Sep 9;333(6048):1453-5. Epub 2011 Aug 4. PubMed PMID: 21817013; PubMed Central PMCID: PMC3170506.*Corresponding authors.

Duncan CG, Yan H. Genomic alterations and the pathogenesis of glioblastoma. Cell Cycle. 2011 Apr 15;10(8):1174-5. Epub 2011 Apr 15. PubMed PMID: 21389786.

Reitman ZJ^, Jin G^, Karoly ED, Spasojevic I, Yang J, Kinzler KW, He Y, Bigner DD, Vogelstein B*, Yan H*. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3270-5. Epub 2011 Feb 2. PubMed PMID: 21289278; PubMed Central PMCID: PMC3044380. *Corresponding authors. ^Equal contribution.

Jin G^, Reitman ZJ^, Spasojevic I, Batinic-Haberle I, Yang J, Schmidt-Kittler O, Bigner DD, Yan H. 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. PLoS One. 2011 Feb 4;6(2):e16812. PubMed PMID: 21326614; PubMed Central PMCID: PMC3033901. *Corresponding authors. ^Equal contribution.

Jin G, Cook S, Cui B, Chen WC, Keir ST, Killela P, Di C, Payne CA, Gregory SG, McLendon R, Bigner DD, Yan H. HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. Neuro Oncol. 2010 Sep;12(9):956-66. Epub 2010 May 14. PubMed PMID: 20472715; PubMed Central PMCID: PMC2940701.

Lopez GY, Reitman ZJ, Solomon D, Waldman T, Bigner DD, McLendon RE, Rosenberg SA, Samuels Y, Yan H. IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. Biochem Biophys Res Commun. 2010 Jul 30;398(3):585-7. Epub 2010 Jul 13. PubMed Central PMCID: PMC2987603.

Reitman ZJ, Yan H. Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst. 2010 Jul 7;102(13):932-41. Epub 2010 May 31. Review. PubMed PMID: 20513808; PubMed Central PMCID: PMC2897878.

Reitman ZJ, Olby NJ, Mariani CL, Thomas R, Breen M, Bigner DD, McLendon RE, Yan H. IDH1 and IDH2 hotspot mutations are not found in canine glioma. Int J Cancer. 2010 Jul 1;127(1):245-6. PubMed PMID: 19877121; PubMed Central PMCID: PMC3498760.

Reitman ZJ, Parsons DW, Yan H. IDH1 and IDH2: not your typical oncogenes. Cancer Cell. 2010 Mar 16;17(3):215-6. PubMed PMID: 20227034.

Kato Y, Jin G, Kuan CT, McLendon RE, Yan H, Bigner DD. A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation. Biochem Biophys Res Commun. 2009 Dec 18;390(3):547-51. Epub 2009 Oct 7. PubMed PMID: 19818334; PubMed Central PMCID: PMC2788025.

Yan H*, Bigner DD, Velculescu V, Parsons DW. Mutant metabolic enzymes are at the origin of gliomas. Cancer Res. 2009 Dec 15;69(24):9157-9. PubMed PMID: 19996293; PubMed Central PMCID: PMC2794981.*Corresponding author.

Yan H^*, Parsons DW*^, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009 Feb 19;360(8):765-73. PubMed PMID: 19228619; PubMed Central PMCID: PMC2820383. *Corresponding authors. ^Equal contribution.

Okezie O Kanu, Ankit Mehta, Chunhui Di, Ningjing Lin, Kathy Bortoff, Darell D Bigner, Hai Yan, David Cory Adamson. Glioblastoma multiforme: a review of therapeutic targets. 2009, Expert opinion on therapeutic targets 13 (6), 701-718

Okezie O Kanu, Betsy Hughes, Chunhui Di, Ningjing Lin, Jinrong Fu, Darell D Bigner, Hai Yan, Cory Adamson. Glioblastoma multiforme oncogenomics and signaling pathways. 2009. Clinical medicine. Oncology 3, CMO. S1008

Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA Jr, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008 Sep 26;321(5897):1807-12. Epub 2008 Sep 4. PubMed PMID: 18772396; PubMed Central PMCID: PMC2820389.

David A Solomon, Jung-Sik Kim, Julia C Cronin, Zita Sibenaller, Timothy Ryken, Steven A Rosenberg, Habtom Ressom, Walter Jean, Darell Bigner, Hai Yan, Yardena Samuels, Todd Waldman. Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. 2008, Cancer research 68 (24), 10300-10306

Chunhui Di, Shaoxi Liao, David C Adamson, Timothy J Parrett, Daniel K Broderick, Qun Shi, Christoph Lengauer, Jordan M Cummins, Victor E Velculescu, Daniel W Fults, Roger E McLendon, Darell D Bigner, Hai Yan. Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. 2005, Cancer research 65 (3), 919-924

Yardena Samuels, Zhenghe Wang, Alberto Bardelli, Natalie Silliman, Janine Ptak, Steve Szabo, Hai Yan, Adi Gazdar, Steven M Powell, Gregory J Riggins, James KV Willson, Sanford Markowitz, Kenneth W Kinzler, Bert Vogelstein, Victor E Velculescu. High Frequency of Mutations of the PIK3CA Gene in Human Cancers. 2004, Science 304 (5670), 554-554

Zhenghe Wang, Dong Shen, D Williams Parsons, Alberto Bardelli, Jason Sager, Steve Szabo, Janine Ptak, Natalie Silliman, Brock A Peters, Michiel S van der Heijden, Giovanni Parmigiani, Hai Yan, Tian-Li Wang, Greg Riggins, Steven M Powell, James KV Willson, Sanford Markowitz, Kenneth W Kinzler, Bert Vogelstein, Victor E Velculescu. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science 304 (5674), 1164-1166

Daniel K Broderick, Chunhui Di, Timothy J Parrett, Yardena R Samuels, Jordan M Cummins, Roger E McLendon, Daniel W Fults, Victor E Velculescu, Darell D Bigner, Hai Yan. Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer research 64 (15), 5048-5050

Devin Dressman, Hai Yan, Giovanni Traverso, Kenneth W Kinzler, Bert Vogelstein. Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. 2003, Proceedings of the National Academy of Sciences 100 (15), 8817-8822

Hai Yan, Weishi Yuan, Victor E Velculescu, Bert Vogelstein, Kenneth W Kinzler. Allelic variation in human gene expression. 2002. Science 297 (5584), 1143-1143

Hai Yan, Zuzana Dobbie, Stephen B Gruber, Sanford Markowitz, Kathy Romans, Francis M Giardiello, Kenneth W Kinzler, Bert Vogelstein. Small changes in expression affect predisposition to tumorigenesis. 2002, Nature genetics 30 (1), 25-26

Tao Liu, Hai Yan, Shannon Kuismanen, Antonio Percesepe, Marie-Louise Bisgaard, Monica Pedroni, Piero Benatti, Kenneth W Kinzler, Bert Vogelstein, Maurizio Ponz de Leon, Päivi Peltomäki, Annika Lindblom. The Role of hPMS1 and hPMS2 in Predisposing to Colorectal Cancer. 2001, Cancer research 61 (21), 7798-7802

Hai Yan, Nickolas Papadopoulos, Giancarlo Marra, Claudia Perrera, Josef Jiricny, C Richard Boland, Henry T Lynch, Robert B Chadwick, Albert De La Chapelle, Karin Berg, James R Eshleman, Weishi Yuan, Sanford Markowitz, Steven J Laken, Christoph Lengauer, Kenneth W Kinzler, Bert Vogelstein. Conversion of diploidy to haploidy. 2000, Nature 403 (6771), 723-724